GTPase, very large interferon inducible pseudogene 2 (GVINP2)

GVINP2 stands for GTPase, very large interferon inducible pseudogene 2. Based on the current scientific literature and data repositories, GVINP2 is not an established functional protein but annotated as a pseudogene. Pseudogenes are sequences related to known genes that do not encode functional proteins due to disablements such as premature stop codons, frameshifts, or regulatory mutations. There is a family of very large interferon-inducible GTPases (VLIGs), such as VLIG-1 in mice, which are involved in cellular responses to type I and II interferons and play a role in innate immunity by conferring cell-autonomous resistance against pathogens[1][5]. Human paralogs include families like Guanylate-binding proteins (GBPs)[2][3][6], but these are distinct from GVINP2. While GTPase proteins such as GBP2 are functional effectors in the immune response and have well-documented biological and disease associations, GVINP2 itself is not recognized as a functional protein, therapeutic target, or receptor. Its "pseudogene" status means it is not actively transcribed and translated to perform a biological function, nor is it involved in known pathophysiological processes or targeted by any drugs. As a result, GVINP2 is not considered a therapeutic target, and entries related to interacting drugs, mechanism of action, or biomarkers are not applicable. This entry is likely the result of confusion with functional GTPases of the VLIG or GBP families. For well-characterized interferon-inducible large GTPases, refer to proteins such as Guanylate-binding protein 2 (GBP2)[6]. However, GVINP2 specifically refers to a non-functional pseudogene, and should not be classified as a genuine protein or target. Summary for mapping: - Name is correct for the pseudogene but not a real protein target. - Should not be considered a target for pharmacological purposes. - Caution: Do not confuse with functional interferon-inducible GTPases like GBP2, IRGs, or VLIGs. Recommendation: Mark as is_target: false and is_incorrect: true because "GVINP2" describes a pseudogene, not a bona fide molecular target. If you are seeking information on the large interferon-inducible GTPases, search for specific functional family members (e.g., "Guanylate-binding protein 2", "very large inducible GTPase-1") rather than for GVINP2.

Other names

GVINP2Guanylate-binding protein pseudogene 2VLIG-2