Guanine monphosphate synthetase, pseudogene

The queried entity is described as a *pseudogene* for guanine monophosphate synthetase, indicating that it does not encode a functional protein product and does not act as a therapeutic target. The functional enzyme—*guanine monophosphate synthetase (GMPS)*—is a bona fide enzyme involved in purine metabolism that catalyzes the conversion of xanthosine monophosphate (XMP) to guanosine monophosphate (GMP) and has documented implications in cancer and metabolic disorders[1][3][4][6]. However, pseudogenes do not possess the same biological activities, and typically are not direct therapeutic targets, nor do they have interacting drugs, disease roles, or known safety concerns as pharmacological targets. "Guanine monphosphate synthetase, pseudogene" is not recognized as a therapeutic or functional biological target in gene or protein databases. Key clarifications: - The correct, protein-coding gene is GMPS (guanine monophosphate synthase), with the canonical Ensembl ID ENSG00000163655[3]. - ENSG00000271027 corresponds to a pseudogene locus, not a protein-coding, active gene. - Pseudogenes like this are generally inconsequential with respect to classic molecular targeting and drug development. If information is needed for the active enzyme GMPS, this should be explicitly specified—otherwise, no therapeutic target data applies to a pseudogene.