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Guanine nucleotide (in DNA) (G)

Target: G
Molecular classification: Nucleobase, Purine

Overview

Guanine is one of the four main nitrogenous bases found in DNA. It pairs specifically with cytosine via three hydrogen bonds and is essential for encoding genetic information. While not a direct drug target itself, its metabolism and role as a building block can be indirectly relevant to certain diseases.

Biological functions

Genetic encodingBase pairingComponent of GTP involved in cellular signaling

Disease associations

Gout (indirectly, through uric acid metabolism)Kidney stones (indirectly, through uric acid metabolism)

Safety considerations

Uric acid buildup leading to gout or kidney stones if metabolism is impaired

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