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Target intelligence / Profile preview
Guanine nucleotide-binding protein G(q) subunit alpha (Gαq)
- Target
- Gαq
- Molecular classification
- G protein, G protein alpha subunit, Signal transduction protein
01
Overview
GNAQ encodes the Gαq subunit, a key component of heterotrimeric G proteins involved in transmembrane signaling. Upon activation by GPCRs, Gαq activates phospholipase C-beta (PLCβ), leading to the production of DAG and IP3, which regulate PKC and calcium signaling, respectively. Mutations in GNAQ, particularly R183Q, are associated with Sturge-Weber syndrome, characterized by abnormal blood vessel formation. Dysregulation of Gαq signaling is also implicated in platelet dysfunction and heart failure.
- Other names
- GNAQG-protein subunit alpha q
02
Mechanism of action
Activates phospholipase C-beta (PLCβ), leading to the production of diacylglycerol (DAG) and inositol trisphosphate (IP3). DAG activates protein kinase C (PKC), and IP3 mobilizes intracellular calcium stores.
03
Biological functions
Signal transductionRegulation of phospholipase C-beta activityCalcium signalingB-cell survivalChemotaxisPlatelet aggregationInsulin-stimulated glucose transport
04
Disease associations
Sturge-Weber syndromePlatelet dysfunctionHeart failureAbnormal vascular proliferation
05
Safety considerations
Constitutive activation due to mutations (e.g., R183Q) can lead to uncontrolled cellular proliferation and vascular abnormalities.Overactivation contributes to heart failure.Dysregulation can lead to platelet dysfunction and increased bleeding risk.
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