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H⁺,K⁺-ATPase

Target: H⁺,K⁺-ATPase
Molecular classification: Enzyme, P-ATPase

Overview

H⁺,K⁺-ATPase, also known as the gastric proton pump, is an enzyme responsible for acidifying the stomach. It is located on the apical membrane of gastric parietal cells and actively transports hydrogen ions (H⁺) out of the cell in exchange for potassium ions (K⁺) from the gastric lumen. This process is essential for gastric acid production. Potassium-competitive acid blockers (P-CABs) target this enzyme to reduce acid secretion.

Other names: Gastric proton pump

Mechanism of action

Reversible competitive inhibition at the potassium-binding site of H⁺,K⁺-ATPase, preventing gastric acid secretion.

Biological functions

Gastric acid secretionIon transport

Disease associations

Gastroesophageal reflux disease (GERD)Peptic ulcer diseaseHelicobacter pylori infection

Interacting drugs

Vonoprazan

3 more in the full profile.

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