H2B clustered histone 19, pseudogene (H2BC19P)

H2B clustered histone 19, pseudogene (H2BC19P), is classified as a **pseudogene** in the human genome, mapping to chromosome 1[1][3][5]. Although its sequence is related to the histone H2B family, which encodes proteins critical for the nucleosome structure of chromatin, H2BC19P does not produce a functional protein product in humans[1][2][4][5]. Instead, it represents a non-coding genomic locus that arose via pseudogenization of ancestral histone genes and remains present in the human genome with no demonstrated biological function or direct involvement in human disease or therapeutic targeting. In other species like cat, pig, horse, and cattle, orthologous loci are functional protein-coding histone genes, but the human H2BC19P is explicitly defined as a pseudogene and is not an actionable target for drugs or diagnostics[2].

Other names

Putative histone H2B type 2-DHIST2H2BDH2B/sH2B/oH2B-clustered histone 19 pseudogeneH2BFOhistone 2, H2bdhistone cluster 2 H2B family member d (pseudogene)histone cluster 2, H2bd (pseudogene)H2BC19P[1][3]