Target intelligence / Profile preview

H3 histone, family 3B (H3F3B)

Target: H3F3B
Molecular classification: Histone, Chromatin component, Epigenetic regulator, Not a receptor, enzyme, or classic cell signaling molecule

Overview

H3 histone, family 3B (H3F3B) encodes a replication-independent histone variant, H3.3B. Histones are basic nuclear proteins that form the nucleosome structure of chromatin—the repeating subunit of DNA packaging in eukaryotes. H3.3B replaces canonical H3 in active chromatin regions, is inserted independently of DNA synthesis, and marks transcriptionally active loci. H3.3B plays critical roles in epigenetic regulation, gene expression, DNA repair, and is particularly essential in non-dividing cells and during spermatogenesis. Mutation or dysregulation can contribute to developmental disorders and some cancers; the gene is not a receptor, transporter, or classic drug target. Note: The query refers to a "pseudogene" (ENSG00000275448), which does not produce functional protein. The actual protein-coding gene of biological significance is H3F3B (ENSG00000132475), not its pseudogene.

Other names: H3.3BH3F3BH3-3BHistone H3.3BHistone H3.3 variantH33

Mechanism of action

Not applicable; H3F3B is not targeted by drugs. General epigenetic drugs (e.g., histone deacetylase inhibitors) may alter histone modification but do not specifically interact with H3.3B

Biological functions

Nucleosome assemblyChromatin compaction and organizationRegulation of gene expression (epigenetics)Transcription regulationDNA repairMeiosis and spermatogenesis

Disease associations

Neurodevelopmental disorder (e.g., Bryant-Li-Bhoj Neurodevelopmental Syndrome 2)Cancer (altered expression in tumors, though not a primary oncogenic target)Epigenetic dysregulation, infertility (especially in spermatogenesis)

Safety considerations

Not applicable for pharmacological intervention, as this is not a direct therapeutic target. In theory, dramatic modification could have profound effects on chromatin, gene expression, and cell viability due to its central role in genome maintenance

Interacting drugs

None specifically target H3F3B or its encoded protein, as it is not a direct drug target

Biomarkers

None validated for patient selection or efficacy monitoring. H3F3B expression or modification states may be of research interest in specific cancers or infertility but are not standard biomarkers

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