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Target intelligence / Profile preview
Haem Detoxification Pathway (Plasmodium falciparum) (HDP)
- Target
- HDP
- Molecular classification
- Enzyme, Metabolic Pathway
01
Overview
The haem detoxification pathway in *Plasmodium falciparum* is a crucial process for neutralizing toxic free haem released during hemoglobin digestion. It involves the polymerization of haem into inert hemozoin crystals within the food vacuole of the parasite. The Heme Detoxification Protein (HDP/PfHDP) is a key enzyme in this pathway, catalyzing the conversion of free haem to hemozoin. This pathway is essential for parasite survival and is targeted by several antimalarial drugs, including chloroquine and artemisinins. The pathway's uniqueness to Plasmodium makes it an attractive drug target.
- Other names
- Heme Detoxification Protein (PfHDP)PF3D7_1446800Heme ligase
02
Mechanism of action
Inhibition of haem polymerization and hemozoin formation.
03
Biological functions
Haem detoxificationHemozoin formationParasite survival
04
Disease associations
MalariaInfection
05
Safety considerations
Potential for drug resistanceOff-target effects of inhibitors
06
Interacting drugs
Chloroquine
1 more in the full profile.
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