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Target intelligence / Profile preview
Haemophilus influenzae type b polysaccharide-protein conjugate (PRP-T) (PRP-T)
- Target
- PRP-T
- Molecular classification
- Vaccine, Conjugate vaccine, Polysaccharide-protein conjugate
01
Overview
Haemophilus influenzae type b polysaccharide-protein conjugate (PRP-T) vaccine is a conjugate vaccine used to prevent invasive diseases caused by Haemophilus influenzae type b (Hib). It consists of the Hib capsular polysaccharide (PRP) covalently linked to tetanus toxoid protein. This conjugation enhances immunogenicity, enabling T-cell dependent immune responses in infants. The vaccine stimulates the production of antibodies against PRP, providing protection against Hib infections.
- Other names
- Hib conjugate vaccineActHIBHiberix
02
Mechanism of action
Stimulates the immune system to produce antibodies against the Haemophilus influenzae type b capsular polysaccharide (PRP), providing protection against Hib infections. The tetanus toxoid carrier protein enhances immunogenicity, particularly in infants.
03
Biological functions
Induction of humoral immunityPrevention of bacterial infectionAntibody productionImmunological memory formation
04
Disease associations
InfectionMeningitis (Haemophilus influenzae type b)Pneumonia (Haemophilus influenzae type b)Epiglottitis (Haemophilus influenzae type b)Septic arthritis (Haemophilus influenzae type b)
05
Safety considerations
Local reactions (redness, swelling)FeverIrritabilityCryingRarely, seizures
06
Biomarkers
Anti-PRP antibody titers
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