Heat shock 70 kDa protein 1A mRNA (HSP70 mRNA) (HSP70 mRNA)

Heat shock 70 kDa protein 1A mRNA (HSP70 mRNA) is the messenger RNA transcript that encodes the HSP70 molecular chaperone, a protein essential for maintaining cellular proteostasis (NCBI Gene: 3303). This mRNA is transcribed from genes such as HSPA1A and HSPA1B in response to various stressors, including heat, oxidative stress, and proteotoxic agents (UniProt: P0DMV8). In many pathological states, particularly cancer, HSP70 mRNA is constitutively overexpressed to facilitate the folding of oncogenic proteins and to inhibit apoptotic signaling pathways (PubMed: 15805467). Therapeutic strategies targeting the mRNA directly, such as small interfering RNAs (siRNAs) or antisense oligonucleotides (ASOs), are designed to silence the expression of the HSP70 protein at the pre-translational level. This depletion sensitizes malignant cells to chemotherapy and radiation by removing the protective chaperone shield (PubMed: 18554153). Beyond oncology, the regulation of HSP70 mRNA is a focus in neurodegenerative research, where modulating its levels may help manage protein aggregation diseases like Alzheimer's or Parkinson's. Current therapeutic challenges include the development of stable delivery systems that can transport RNA-targeting agents into the cytoplasm of target cells without triggering significant immune responses. While small molecule inhibitors typically target the ATP-binding domain of the HSP70 protein, mRNA-targeted approaches offer a distinct strategy to prevent the protein from being synthesized entirely.

Other names

HSPA1A mRNAHSPA1B mRNAHSP72 mRNAHeat shock 70 kDa protein 1 mRNAHeat shock 70 kDa protein 2 mRNA

Targeting HSP70 mRNA typically involves the use of RNA interference (RNAi) or antisense oligonucleotides (ASOs) to induce the degradation of the transcript or block its translation, thereby reducing the levels of the functional HSP70 protein (PubMed: 18554153).