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Target intelligence / Profile preview
Heat Shock Protein 65 (Mycobacterium bovis) (HSP65)
- Target
- HSP65
- Molecular classification
- Heat Shock Protein, Chaperonin, hsp60 family
01
Overview
Heat shock protein 65 (HSP65) from *Mycobacterium bovis* is a highly conserved molecular chaperone that protects cells against stress. It's an immunodominant antigen recognized by the host immune system and plays a role in both protective immunity against tuberculosis and potentially in autoimmunity. Expression increases upon stress and it is involved in TLR4 signaling. Primarily studied as a vaccine target and for immunological research.
- Other names
- Cpn60-2groEL protein-265 kDa antigenCell wall protein AAntigen AgroL2groEL-2
02
Mechanism of action
Not applicable; target is not directly drug-targeted but used in vaccine research and immunological studies.
03
Biological functions
Molecular chaperoneProtein foldingStress responseImmune responsePrevention of protein aggregation
04
Disease associations
TuberculosisAutoimmunityInfection
05
Safety considerations
Potential for autoimmune reactions due to molecular mimicry between microbial and host antigens.
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