Heat shock transcription factor family, X-linked 2 (HSFX2)

Heat shock transcription factor family, X-linked 2 (HSFX2) is a protein-coding gene located on the X chromosome and encodes a predicted DNA-binding transcription factor implicated in the regulation of transcription by RNA polymerase II. HSFX2 is primarily characterized by nuclear localization and is involved in sequence-specific DNA binding, playing a role in gene regulation but is not currently considered a direct therapeutic target. It has rare clinical associations, most notably with Partington syndrome and hypogonadotropic hypogonadism, but is not known to be strongly linked to major common diseases or to interact with approved drugs. Its closest known paralog is HSFX1, with which it shares structural features and evolutionary relationships

Other names

HSFX2Heat shock transcription factor family, X-linked, HSFX2LW-1 (rare or historical use)Heat shock transcription factor, X-linked, HSFX1 (Note: HSFX1 is a paralog, not a strict alias)

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