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Target intelligence / Profile preview
Hemagglutinin (Influenza type-B) (HA (Influenza B))
- Target
- HA (Influenza B)
- Molecular classification
- Glycoprotein, Viral Surface Protein, Receptor Ligand
01
Overview
Hemagglutinin (HA) is the major surface glycoprotein of the influenza B virus, essential for viral entry into host cells. It mediates receptor binding and membrane fusion. HA is a key target for neutralizing antibodies, but its rapid evolution necessitates frequent vaccine updates.
- Other names
- Influenza B HemagglutininHAHemagglutinin
02
Mechanism of action
Binding to sialic acid receptors on host cells and mediating fusion of the viral and host cell membranes.
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune recognitionHemagglutination
04
Disease associations
Infection
05
Safety considerations
Antigenic drift (vaccine escape)Potential for resistance to antiviral antibodies/fusion inhibitors
06
Interacting drugs
Anti-influenza antibodies
2 more in the full profile.
07
Biomarkers
HA antibody titers (vaccine efficacy)HA sequence variations (antigenic drift)
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