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Target intelligence / Profile preview
Hemagglutinin Protein (Influenza A Virus) (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral fusion protein, Class I viral fusion protein
01
Overview
Hemagglutinin (HA) is a homotrimeric glycoprotein and the most abundant surface protein on the influenza A virus. It mediates both attachment to host cells and fusion of viral and cellular membranes. HA is essential for influenza virus entry, making it a primary target for neutralizing antibodies and antiviral strategies.
- Other names
- HemagglutininHA proteinInfluenza hemagglutinin
02
Mechanism of action
Inhibition of receptor binding or membrane fusion
03
Biological functions
Receptor binding (sialic acid)Membrane fusionViral entryAgglutination
04
Disease associations
InfectionInfluenzaPandemic potential
05
Safety considerations
Antigenic drift and shift leading to resistancePotential for off-target effects of inhibitors
06
Interacting drugs
NA inhibitors (indirectly, by preventing virus release)
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