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Hemagglutinin Protein (Influenza B-Victoria Lineage)
- Molecular classification
- Glycoprotein, Viral protein, Hemagglutinin
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of the Influenza B virus, specifically from the Victoria lineage. It plays a critical role in viral entry by binding to sialic acid receptors on host cells and mediating membrane fusion. The HA protein is also the primary target for neutralizing antibodies and is central to vaccine design. It forms homotrimers on the virion surface, with each monomer consisting of HA1 (receptor-binding) and HA2 (fusion domain) subunits. Antigenic drift in HA can lead to reduced vaccine effectiveness. The B/Victoria lineage primarily infects children at higher rates compared with Yamagata-lineage viruses.
- Other names
- HA (Influenza B-Victoria)Influenza B HemagglutininB/Washington/02/2019 HA
02
Mechanism of action
Attachment to sialic acid receptors on host cells, mediating membrane fusion
03
Biological functions
Viral attachmentMembrane fusionReceptor bindingAntigen presentationImmune response
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for immune escape mutantsRisk of antibody-dependent enhancement (ADE) in certain contexts
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir)
1 more in the full profile.
07
Biomarkers
HA antibody titers (vaccine efficacy)HA sequence variations (antigenic drift)
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