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Target intelligence / Profile preview
Hemagglutinin protein of influenza A (H1N1) (HA)
- Target
- HA
- Molecular classification
- Viral envelope glycoprotein, Class I fusion protein
01
Overview
The hemagglutinin protein of influenza A (H1N1) is an essential class I viral fusion glycoprotein that enables virus entry into host cells through receptor recognition and subsequent membrane fusion. Its structural features make it both critical to pathogenesis and highly immunogenic, driving ongoing efforts toward improved vaccines and therapeutics targeting this molecule.
- Other names
- H1N1 hemagglutininHA proteinInfluenza A hemagglutinin
02
Mechanism of action
Inhibition of receptor binding or membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune response elicitation
04
Disease associations
InfectionInfluenzaPandemic
05
Safety considerations
Antigenic variation (drift and shift)Development of drug resistancePotential for antibody-dependent enhancement (ADE)
06
Interacting drugs
Oseltamivir (targets neuraminidase but impacts HA function indirectly)
1 more in the full profile.
07
Biomarkers
HA antibody titer (for vaccine efficacy)HA sequence (for strain identification and vaccine matching)
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