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Hemagglutinin Protein of Influenza B Virus (B Victoria Lineage)
- Molecular classification
- Glycoprotein, Viral Surface Protein
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of the influenza B virus (B Victoria lineage), responsible for binding to host cell receptors and facilitating viral entry. It is a key target for neutralizing antibodies and a crucial component in vaccine formulations. The Victoria lineage is antigenically distinct from the Yamagata lineage, necessitating their co-inclusion in quadrivalent vaccines.
- Other names
- HA (Influenza B Victoria Lineage)Influenza B Hemagglutinin (Victoria)B/Victoria lineage Hemagglutinin
02
Mechanism of action
Neutralization of viral entry by antibody binding to hemagglutinin.
03
Biological functions
Viral attachmentViral entryMembrane fusionAntigen presentationImmune response induction
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for antigenic drift leading to vaccine mismatch.Risk of escape mutants with altered hemagglutinin sequences.
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