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Heme detoxification pathway (Plasmodium)

Molecular classification: Enzyme

Overview

The heme detoxification pathway in Plasmodium species, particularly *Plasmodium falciparum*, is a critical biochemical process that enables the parasite to survive within host red blood cells by polymerizing toxic free heme into inert crystalline hemozoin. Several antimalarial drugs act by inhibiting or disrupting hemozoin formation, leading to accumulation of toxic free heme and parasite death.

Mechanism of action

Inhibition of hemozoin formation or disruption of heme detoxification process, leading to accumulation of toxic free heme.

Biological functions

DetoxificationHeme polymerization

Disease associations

Infection

Safety considerations

Resistance development due to changes in digestive vacuole physiology.Potential off-target effects of drugs inhibiting heme detoxification.

Interacting drugs

Chloroquine

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