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Target intelligence / Profile preview
Heparan Sulfate Proteoglycans (HSPGs) (HSPGs)
- Target
- HSPGs
- Molecular classification
- Proteoglycans, Glycosaminoglycans
01
Overview
Heparan sulfate proteoglycans (HSPGs) are a family of complex carbohydrates present on cell surfaces and in the extracellular matrix. They serve as initial attachment receptors for Human Papillomavirus (HPV). Blocking the interaction between HPV's L1 capsid protein and HSPGs prevents viral entry, making HSPG binding a therapeutic target for antiviral strategies. Inhibitors or antibodies targeting this interaction can potentially prevent persistent HPV infections.
- Other names
- HSPG
02
Mechanism of action
Inhibition of HPV virion binding to heparan sulfate proteoglycans, preventing viral entry into host cells.
03
Biological functions
Cell adhesionGrowth factor signalingExtracellular matrix organizationViral attachment
04
Disease associations
CancerInfectionInflammation
05
Safety considerations
Potential for off-target effects due to the widespread distribution of HSPGs in the body.Development of resistance by HPV through alternative entry mechanisms.
06
Interacting drugs
Matrix metalloproteinase inhibitors
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