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Hepatitis B Virus DNA Polymerase (Reverse Transcriptase) (None)
- Target
- None
- Molecular classification
- Enzyme, Reverse Transcriptase, Polymerase
01
Overview
Hepatitis B virus (HBV) DNA polymerase, also known as reverse transcriptase (RT), is a multifunctional viral enzyme essential for HBV replication. It catalyzes the conversion of pre-genomic RNA (pgRNA) into relaxed circular DNA (rcDNA) within the viral capsid, a process central to the HBV life cycle. It is a key target for antiviral therapies.
- Other names
- HBV DNA polymeraseReverse transcriptase (HBV)HBV RT
02
Mechanism of action
Nucleos(t)ide analogs inhibit HBV DNA polymerase activity, disrupting viral replication.
03
Biological functions
Protein primingReverse transcriptionRNA-dependent DNA synthesisDNA-dependent DNA synthesisRNase H activityViral genome replication
04
Disease associations
Hepatitis BChronic hepatitis BLiver diseaseViral infection
05
Safety considerations
Drug resistanceIncomplete viral eradication (cccDNA persistence)Adverse effects of nucleos(t)ide analogs
06
Interacting drugs
Entecavir
4 more in the full profile.
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