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Target intelligence / Profile preview
Hepatitis C virus antigen (polyprotein)
- Molecular classification
- Viral protein, Polyprotein
01
Overview
The Hepatitis C virus antigen, or polyprotein, is a large precursor protein encoded by the viral genome. It is processed by host and viral proteases to produce all the mature structural (Core, E1, E2, p7) and nonstructural (NS2, NS3, NS4A, NS4B, NS5A, NS5B) proteins essential for viral replication and assembly. It is a key target for direct-acting antiviral drugs.
02
Mechanism of action
Inhibition of viral protease activity; Inhibition of viral RNA-dependent RNA polymerase; Inhibition of NS5A function
03
Biological functions
Precursor protein processingCapsid formationRNA bindingEnvelope fusionProteolysisPolymerizationReplication
04
Disease associations
InfectionHepatitis C
05
Safety considerations
Drug-drug interactionsTreatment failure due to resistanceLiver toxicity
06
Interacting drugs
NS3/4A protease inhibitors (e.g., Grazoprevir, Glecaprevir, Voxilaprevir)
2 more in the full profile.
07
Biomarkers
HCV RNA levelsHCV genotypeLiver function tests (ALT, AST)
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