Hepatocyte growth factor receptor mRNA 3' untranslated region (MET mRNA 3' UTR) (MET mRNA 3' UTR)

The Hepatocyte growth factor receptor (MET) mRNA 3' untranslated region (3' UTR) is a critical regulatory segment of the MET transcript that governs protein expression levels through post-transcriptional mechanisms. This region contains multiple binding sites for microRNAs (miRNAs), such as miR-34a, miR-1, and miR-206, which normally act to suppress MET expression by promoting mRNA degradation or inhibiting translation (Migliore et al., 2008, Nature Genetics). In many human cancers, including lung, gastric, and hepatic carcinomas, the MET protein is overexpressed due to the loss of these inhibitory miRNAs or mutations within the 3' UTR, leading to constitutive activation of the HGF/MET signaling pathway (Yan et al., 2015, Molecular Cancer). Therapeutic targeting of the MET mRNA 3' UTR involves the use of miRNA mimics or antisense oligonucleotides (ASOs) designed to restore or enhance the natural suppressive regulation of the gene. By reducing the overall abundance of MET protein, these RNA-targeted therapies can effectively inhibit tumor cell proliferation, survival, and epithelial-to-mesenchymal transition (EMT), offering a potential solution to overcome resistance seen with traditional small-molecule kinase inhibitors.

Other names

c-Met mRNA 3' UTRMET 3' UTRHGFR mRNA 3' UTR3' untranslated region of the MET transcript

Induction of mRNA degradation and translational repression via RNA interference or steric blocking of the 3' untranslated region.