High mobility group box 3 mRNA 3' untranslated region (HMGB3 mRNA 3'UTR)

The High mobility group box 3 (HMGB3) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the HMGB3 transcript that governs its stability and translation efficiency (Source: PubMed, PMID: 28656247). HMGB3 itself is a DNA-binding protein involved in DNA replication, recombination, and repair, and its dysregulation is frequently observed in various malignancies (Source: UniProt, O15347). The 3'UTR contains multiple binding sites for microRNAs (miRNAs), such as miR-205 and miR-532-5p, which act as tumor suppressors by inhibiting HMGB3 expression (Source: PubMed, PMID: 26464616). In many cancers, the loss of these regulatory miRNAs or alterations in the 3'UTR leads to HMGB3 overexpression, promoting cell proliferation, migration, and epithelial-mesenchymal transition (Source: PubMed, PMID: 31233475). Consequently, the HMGB3 mRNA 3'UTR is considered a viable therapeutic target for RNA-based interventions, including antisense oligonucleotides (ASOs) and miRNA mimics, designed to restore normal regulatory control (Source: PubMed, PMID: 30106434). Targeting this region aims to suppress the oncogenic activity of HMGB3 and sensitize cancer cells to conventional therapies.

Other names

HMGB3 3'-UTRHigh mobility group protein B3 mRNA 3' untranslated regionHMG2A mRNA 3'UTRHigh mobility group protein 2-like 1 mRNA 3'UTR

Binding of antisense oligonucleotides or microRNAs to the 3'UTR sequence leads to mRNA degradation or translational inhibition, thereby reducing the expression of the HMGB3 protein.