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Target intelligence / Profile preview
Histamine Release (Increased)
- Molecular classification
- Immunological event, Cellular process
01
Overview
Histamine release refers to a critical immunological event where stored histamine is expelled from mast cells/basophils—primarily via IgE-mediated mechanisms—leading to diverse physiological effects depending on which tissue-specific receptors are activated. This process underpins many allergic/inflammatory conditions but also has broader regulatory roles across multiple organ systems.
- Other names
- Histamine degranulationMast cell degranulationBasophil degranulation
02
Mechanism of action
H1 receptor inverse agonism, mast cell stabilization
03
Biological functions
Immune responseInflammationAllergic reactionVasodilationBronchoconstrictionNeurotransmitter release modulation
04
Disease associations
Allergic rhinitisAsthmaUrticariaAutoimmune disordersInflammatory diseases
05
Safety considerations
Systemic effects of histamine release (e.g., anaphylaxis)Side effects of antihistamines (e.g., drowsiness)
06
Interacting drugs
Antihistamines
4 more in the full profile.
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