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Histamine Release (via Immune Response)
- Molecular classification
- Cellular process, Immune response, Signaling pathway
01
Overview
Histamine release via the immune system is a process where mast cells and basophils, upon activation (typically by IgE cross-linking), release histamine. This release triggers various physiological effects mediated by histamine receptors (H1R-H4R). It is a central event in allergic reactions and other inflammatory conditions, leading to vasodilation, bronchoconstriction, pruritus, and chemotaxis of immune cells. Antihistamines can block the histamine receptors. Severe reactions like anaphylaxis require epinephrine.
02
Mechanism of action
Block histamine receptor activation; Counteract physiological effects of histamine
03
Biological functions
Immune responseInflammationVasodilationBronchoconstrictionChemotaxisRegulation of cytokine production
04
Disease associations
AllergiesAnaphylaxisAsthmaAllergic rhinitisConjunctivitisHivesFood allergiesInflammation
05
Safety considerations
Excessive or inappropriate histamine releaseAnaphylaxis
06
Interacting drugs
Antihistamines
1 more in the full profile.
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