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Target intelligence / Profile preview
Histamine release (via immune response to Ctenocephalides canis antigen)
- Molecular classification
- Non-standardized insect allergenic extract, Antigen
01
Overview
Histamine release in this context refers to the process by which histamine, a key inflammatory mediator, is liberated from immune cells—primarily mast cells and basophils—in response to antigens derived from *Ctenocephalides canis* (the dog flea). This mechanism is central to the pathogenesis of flea allergy dermatitis (FAD) in dogs and other susceptible animals.
- Other names
- Dog Flea Allergenic ExtractCtenocephalides canisCTENOCEPHALUS CANISPubChem UNII: LN7IM9RDEA
02
Mechanism of action
IgE-mediated mast cell degranulation leading to histamine release and downstream allergic symptoms.
03
Biological functions
Immune responseInflammationAllergic reactionMast cell degranulationHistamine release
04
Disease associations
Flea allergy dermatitisPruritusErythemaAllergic skin disease
05
Safety considerations
Potential for severe allergic reactionsEfficacy can be variable depending on the specific antigens and individual sensitivity
06
Interacting drugs
Antihistamines
1 more in the full profile.
07
Biomarkers
Wheal-and-flare reaction in intradermal skin test
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