Histone cluster 3, H3 pseudogene (HIST3H3)

This entry corresponds to a pseudogene associated with the cluster of histone H3 genes. Unlike functional histone H3 genes, which encode core components of the nucleosome and play roles in chromatin structure, gene regulation, and epigenetic modification, pseudogenes like HIST3H3 are non-functional DNA segments that resemble known genes but do not encode an active protein product. Pseudogenes may arise from duplication or retrotransposition events and, while occasionally expressed as RNA, generally do not contribute to canonical histone protein function in the cell[1][3][4]. Therefore, this pseudogene is not a gene product or receptor for drugs, is not considered a therapeutic target, and has no direct disease association, drug interactions, mechanism of action, or biomarker relevance. The target is not suitable for inclusion as a therapeutic target. It is a non-coding and likely non-functional pseudogene, not a receptor, enzyme, transporter, or part of a recognized molecular target family[1][3][4].

Other names

H3-4H3.4 histone, cluster memberHIST3H3