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Target intelligence / Profile preview
Histone Deacetylase (pan) (HDAC)
- Target
- HDAC
- Molecular classification
- Enzyme, Histone modification
01
Overview
Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues on histones and non-histone proteins, leading to chromatin condensation and transcriptional repression. The term "pan-HDAC" refers to agents or inhibitors that target multiple HDAC isoforms across different classes. Inhibition of pan-HDAC results in global hyperacetylation with broad changes in cellular function. They are investigated mainly for oncology indications but also neurological/fibrotic diseases.
- Other names
- HDAC (pan)Pan-HDACHistone deacetylase
02
Mechanism of action
Pan-HDAC inhibitors block the activity of multiple or all classical zinc-dependent HDAC isoforms, leading to hyperacetylation of histones and altered gene expression profiles.
03
Biological functions
Chromatin remodelingCell cycle controlSignal transductionTranscriptional repressionEpigenetic regulation
04
Disease associations
CancerFibrosis-related diseasesNeurodegenerative diseasePsychiatric disorders
05
Safety considerations
Vascular complicationsImmune modulation
06
Interacting drugs
Vorinostat (SAHA)
2 more in the full profile.
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