Histone deacetylase 1, 2, 3, and 10 (HDAC1, HDAC2, HDAC3, HDAC10)

Histone deacetylase 1, 2, 3, and 10 are members of the histone deacetylase enzyme family, which remove acetyl groups from lysine residues on histone proteins, leading to chromatin condensation and transcriptional repression. These enzymes play critical roles in regulating gene expression, cell cycle progression, apoptosis, and development. Aberrant function of these enzymes contributes to the pathogenesis of diseases such as cancer, neurodegeneration, and inflammatory disorders. Therapeutic inhibitors targeting HDACs, particularly class I (HDAC1, HDAC2, HDAC3) and class IIb (HDAC10), are used in cancer treatment and are under investigation for other diseases. Each isoform has unique biological and pathological roles, necessitating specific characterization and targeting for therapeutic purposes.

Other names

HDAC1HDAC2HDAC3HDAC10Histone deacetylases (general class)Lysine deacetylases

Inhibition of deacetylase activity, resulting in hyperacetylation of histones and transcriptional activation of silenced genes (leading to cell cycle arrest/differentiation/apoptosis in tumor cells); Modulation of acetylation state on non-histone proteins affecting cell growth, survival, and apoptosis