Histone deacetylase 1 messenger RNA 3' untranslated region (HDAC1 mRNA 3' UTR) (HDAC1 mRNA 3' UTR)

The Histone deacetylase 1 (HDAC1) messenger RNA 3' untranslated region (UTR) is a critical regulatory segment of the HDAC1 transcript that governs the stability and translation of the HDAC1 protein (UniProt, P19367). This region contains multiple binding sites for microRNAs (miRNAs) such as miR-34a, miR-449a, and miR-520h, which act as tumor suppressors by downregulating HDAC1 expression post-transcriptionally (PubMed, 21135165; PubMed, 25670461). In many cancers, including prostate, breast, and lung cancer, the regulatory control of the HDAC1 3' UTR is often bypassed or disrupted, leading to the overexpression of HDAC1, which promotes cell cycle progression, inhibits apoptosis, and facilitates tumor growth (PubMed, 19383914). Consequently, the HDAC1 mRNA 3' UTR has emerged as a significant therapeutic target for RNA-based interventions, including miRNA mimics and antisense oligonucleotides (ASOs). These strategies aim to reduce HDAC1 protein levels by inducing mRNA degradation or blocking translation, thereby restoring normal epigenetic regulation and inhibiting oncogenic pathways (PubMed, 23340171).

Other names

HDAC1 3' UTRHistone deacetylase 1 3-prime untranslated regionHDAC1 mRNA regulatory regionHDAC1 3-UTR

RNA interference and antisense-mediated degradation or translational inhibition of HDAC1 mRNA