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Target intelligence / Profile preview
HIV-1 Envelope Glycoprotein Trimer (V2 Apex Region) (Env)
- Target
- Env
- Molecular classification
- Glycoprotein, Viral protein, Membrane protein
01
Overview
The HIV-1 envelope glycoprotein trimer (Env) is a complex, metastable structure on the surface of the human immunodeficiency virus type 1 (HIV-1). It is responsible for mediating viral entry into host cells and serves as the sole virus-specific target for neutralizing antibodies. The V2 apex refers specifically to a quaternary epitope located at the tip formed by convergence of V2 loops from all three gp120 protomers in the native trimeric structure. The V2 apex is considered one of several major sites targeted by bnAbs capable of neutralizing diverse HIV strains.
- Other names
- HIV-1 Env trimergp120-gp41V2 Apex
02
Mechanism of action
Antibody-mediated neutralization of viral entry
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune evasion
04
Disease associations
InfectionHIV-1 pathogenesis
05
Safety considerations
Immune escapeGlycosylation masking of epitopesConformational flexibilityElicitation of non-neutralizing antibodies
06
Interacting drugs
Broadly neutralizing antibodies (bnAbs)
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