HLA-A*02:01-presented Human Papillomavirus type 16 E6 (29-38) peptide complex (HLA-A*02:01/HPV16 E6(29-38))

The HLA-A*02:01-presented HPV16 E6 29-38 peptide is a specific peptide-major histocompatibility complex (pMHC) found on the surface of cells infected with Human Papillomavirus type 16 (HPV16) or HPV16-transformed malignant cells. The complex consists of the HLA-A*02:01 allele presenting a 10-amino acid epitope (TIHDIILECV) derived from the E6 oncoprotein, a primary driver of HPV-mediated oncogenesis through the degradation of the p53 tumor suppressor (PubMed: 28811044). This pMHC complex serves as a critical recognition element for the cellular immune system, specifically for CD8+ cytotoxic T lymphocytes (CTLs) equipped with T-cell receptors (TCRs) specific to this epitope (NIH: NCT02858310). Because E6 is an intracellular viral protein, its fragments can only be targeted}

Other names

HPV16 E6 29-38/HLA-A*02:01 complexTIHDIILECV-HLA-A*02:01 complexE6 29-38 peptide-MHC complexHPV16 E6(29-38) antigen

T-cell receptor (TCR) mediated recognition leading to T-cell activation, cytokine secretion, and cytotoxic lysis of target cells.