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HLA class II histocompatibility antigen, DQ(6) alpha chain (HLA-DQA2)
- Target
- HLA-DQA2
- Molecular classification
- Cell surface receptor, MHC class II protein
01
Overview
HLA-DQA2 is an MHC class II alpha chain protein that forms a heterodimer with a class II beta chain. It plays a crucial role in the adaptive immune response by binding and presenting processed antigens to CD4+ T-helper cells. This interaction is essential for initiating and regulating immune responses against pathogens and self-antigens. Its expression is primarily found on antigen-presenting cells such as B lymphocytes, dendritic cells, and macrophages. Heightened expression may correlate with reduced susceptibility to certain infections.
- Other names
- HLA-DXADQ(6) alpha chainDAAP-381D23.2
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationImmune responseT-cell activationPeptide binding
04
Disease associations
InfectionAutoimmunityImmune dysregulation
05
Safety considerations
Potential for immune-related adverse eventsRisk of autoimmunity
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