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HLA complex group 25 (HCG25) is classified as a non-coding RNA gene located on human chromosome 6 within the major histocompatibility complex (MHC, also called the HLA complex)[3][6][8]. Unlike protein-coding HLA genes (such as HLA-A25), HCG25 does not encode a cell surface protein and its precise biological function remains unclear. There are no known roles in antigen presentation or disease association, and it is not recognized as a target for therapeutics or drug interactions[3][6]. It is often listed among non-coding RNA elements annotated within the HLA region in genomic databases, but its biological impact requires further research. Note: It is important not to confuse HCG25 (non-coding RNA) with HLA-A*25 or HLA-A25, which are classical MHC class I antigens critical in immune response and transplantation medicine[1][5][6].
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