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HLA complex group 27 (non-protein coding) (HCG27)
- Target
- HCG27
- Molecular classification
- Other (long non-coding RNA, lncRNA)
01
Overview
HLA complex group 27 (HCG27) is a long non-coding RNA gene (lncRNA) found within the HLA class I region of the human genome[4]. It does not encode a protein and is not classified as a receptor, enzyme, transporter, or classical drug target. Its alternative names reflect various database annotations and clone IDs. While the HLA region is densely packed with immune-related genes including classical HLA-B27 protein-coding alleles—well-known for their association with disorders such as ankylosing spondylitis—the HCG27 lncRNA itself is not known to have a direct biological function, disease role, or utility as a therapeutic target[4]. There is no evidence for direct drug interaction, mechanism of drug action, or use as a biomarker. HCG27 should not be confused with HLA-B27, which is a major MHC class I protein receptor implicated in immune recognition and multiple diseases[1][2][3].
- Other names
- bPG299F13.9bCX101P6.9bQB115I13.2FLJ40123HCG27 (non-protein coding)
02
Biological functions
Other (Putative regulatory RNA; specific biological functions have not been clearly established)
03
Disease associations
Other (No strongly established disease roles; possible involvement in immune regulation within the MHC region, but not directly implicated as a therapeutic target in major diseases)
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