Host Antimicrobial Peptide Induction (e.g., Cathelicidin) (AMP Induction)

Host antimicrobial peptide (AMP) induction involves upregulating endogenous peptides, such as cathelicidins (e.g., LL-37 in humans), as part of the innate immune system. These peptides are produced by various host cells in response to infection or inflammation, providing a broad-spectrum defense against pathogens. Cathelicidins act by disrupting microbial membranes and modulating immune responses. Their expression is induced by PAMPs, cytokines like IL-1β, and vitamin D3. Pathogens can evade AMP activity through various mechanisms. AMP induction represents a promising therapeutic approach for treating infections and modulating inflammation, although careful consideration of potential safety concerns is necessary.

Other names

Antimicrobial Peptide UpregulationCathelicidin InductionLL-37 InductionhCAP18 Induction

Induction of endogenous antimicrobial peptide expression, leading to direct microbial killing through membrane disruption and immunomodulatory effects.