House dust mite allergen (specifically, individual proteins such as Der p 1, Der p 2, Der p 10, or Der p 23) (None)

House dust mite proteins are a group of potent environmental allergens derived from mites such as Dermatophagoides pteronyssinus. The most clinically relevant molecules are known as major allergens—examples include Der p 1 (a cysteine protease), Der f 1, Der p 10 (tropomyosin), and Der p 23 (a peritrophin-like protein). These proteins elicit strong IgE responses in sensitized individuals and play a central role in the pathogenesis of allergic diseases including asthma and rhinitis. They act by binding to IgE on mast cells and basophils, triggering degranulation and release of inflammatory mediators. Some house dust mite proteins also have enzymatic activity that can disrupt epithelial barriers or modulate immune responses. Because they are major triggers for respiratory allergies worldwide, these molecules serve both as diagnostic markers for allergy testing and therapeutic targets for desensitization therapies such as subcutaneous or sublingual immunotherapy[1][2]. Note: The entry “House dust mite protein” is not sufficiently specific—it refers to a family containing many distinct molecular entities with different structures/functions. For structured data purposes it is recommended to use the precise name/abbreviation for each individual allergenic molecule when possible[5].

Other names

House dust mite allergenDermatophagoides pteronyssinus allergenHDM allergen

Induction of immune tolerance via desensitization in immunotherapy