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Target intelligence / Profile preview
Human CD34-CD7+ T cell progenitor
- Molecular classification
- Hematopoietic cell, Lymphoid progenitor
01
Overview
The human CD34−CD7+ T cell progenitor is a hematopoietic cell population characterized by the absence of the stem/progenitor marker CD34 and the presence of the early lymphoid/T-lineage marker CD7. This phenotype distinguishes it from earlier progenitors and marks a more differentiated stage within T-cell development. These cells represent an intermediate stage in human T-cell lineage commitment and can reconstitute thymic function in vivo, indicating their functional capacity as true T-lineage progenitors.
- Other names
- CD34-CD7+ T cell progenitorCD34 negative CD7 positive T cell progenitorPro-T Cell Stage II/III
02
Biological functions
T-cell differentiationThymic reconstitutionImmune reconstitutionT-lineage commitment
03
Disease associations
ImmunodeficiencyHematopoietic disorders
04
Safety considerations
Graft-versus-host disease (GvHD) potential upon transplantationRisk of aberrant T-cell development or leukemic transformation
05
Biomarkers
CD34CD7
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