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Human enzymes are biologically active proteins that catalyze a vast array of chemical reactions within cells, playing essential roles in metabolic pathways, DNA/RNA synthesis and degradation, cell signaling, and other physiological processes. Because their functions are so central to cell biology, many drugs are designed to interact with specific human enzymes to modulate their activity, underlying the basis for treatment of numerous diseases. However, "human enzymes" represents thousands of different proteins across multiple families and subclasses, and the term is not specific enough to indicate a single therapeutic target. Each enzyme is described by a unique full name, function, and disease relevance[8][4][6][2].
Inhibition (many drugs inhibit enzymatic activity); Activation (fewer drugs activate enzymes); Modulation via allosteric sites; Covalent modification
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