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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Antigen (Gag p17) (p17)
- Target
- p17
- Molecular classification
- Retroviral matrix protein
01
Overview
The HIV-1 Gag p17 protein, also known as the matrix protein p17 or MA, is a structural component of the human immunodeficiency virus type 1 (HIV-1). It is essential for virus particle assembly and plays roles in viral replication and immune modulation. Extracellular p17 deregulates functions in various immune cells and promotes T-cell proliferation and proinflammatory cytokine release after binding cellular receptors such as HSPGs and chemokine receptors CXCR1/CXCR2.
- Other names
- Matrix protein p17MAHIV-1 Gag p17 protein
02
Mechanism of action
N/A
03
Biological functions
Structural supportViral assemblyViral buddingImmune modulationT-cell activationT-cell proliferation
04
Disease associations
AIDS progressionHIV-associated non-Hodgkin lymphoma (NHL)Infection
05
Safety considerations
Extracellular p17 accumulation in tissues even during effective antiretroviral therapy.Deregulates functions in various immune cells implicated in AIDS pathogenesis.Certain variants can activate PI3K/Akt signaling pathways potentially contributing to increased B-cell proliferation and lymphomagenesis
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