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Target intelligence / Profile preview
Human Leukocyte Antigen A*01:01 (HLA-A*01:01)
- Target
- HLA-A*01:01
- Molecular classification
- MHC class I antigen, Transmembrane glycoprotein
01
Overview
Human Leukocyte Antigen A*01:01 (HLA-A*01:01) is an allele of the HLA-A gene, encoding an MHC class I cell surface antigen. It presents intracellular peptides to CD8+ cytotoxic T cells, playing a vital role in immune surveillance and defense against infected or malignant cells. Its main function is to present peptides and mediate interactions of immune cells with the surfaces of other cells.
- Other names
- HLA-A1A1
02
Mechanism of action
Not applicable - HLA-A*01:01 is a target for immune recognition, not a drug target in itself. Drugs may influence its expression or downstream effects.
03
Biological functions
Antigen presentationImmune regulationT-cell activationNK cell modulation
04
Disease associations
Transplant rejectionAutoimmune disease susceptibilityInfection susceptibility/resistance
05
Safety considerations
Mismatched HLA-A*01:01 can lead to transplant rejectionAssociation with certain autoimmune conditions may warrant monitoring in susceptible individuals
06
Biomarkers
HLA-A*01:01 status can be a biomarker for transplantation compatibilityHLA-A*01:01 presence as a biomarker for disease risk/susceptibility
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