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Target intelligence / Profile preview
Human Leukocyte Antigen A*02
- Molecular classification
- Class I MHC, Receptor
01
Overview
HLA-A*02 is a specific allele group within the HLA-A locus, a class I MHC molecule, that presents endogenous peptides to CD8+ T cells. It plays a crucial role in immune surveillance and is implicated in various diseases, including infections, autoimmune disorders, and cancer. Specific variants, such as HLA-A*02:01, are frequently referenced in clinical contexts, including transplantation and cancer immunotherapy.
- Other names
- HLA-A*02HLA-A*02:01
02
Biological functions
Antigen presentationImmune responseT cell activation
03
Disease associations
InfectionAutoimmunityCancerTransplant rejection
04
Safety considerations
Potential for off-target effects in immunotherapyRisk of cytokine release syndrome in immunotherapyGraft-versus-host disease (GVHD) in transplantation
05
Biomarkers
HLA-A*02 status (e.g., for clinical trial eligibility for certain immunotherapies)Peptide-HLA complex formation as a biomarker for immune response
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