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Human Leukocyte Antigen A*0201–HPV16 E7 Peptide Complex (HLA-A*0201-HPV16 E7)
- Target
- HLA-A*0201-HPV16 E7
- Molecular classification
- Receptor, Peptide-MHC complex
01
Overview
The Human leukocyte antigen (HLA) A*0201–HPV16 E7 peptide complex is a molecular structure formed by the binding of a specific peptide derived from the human papillomavirus type 16 (HPV16) E7 protein to the HLA-A*02:01 molecule, a class I major histocompatibility complex (MHC) protein found on human cells. This complex plays a critical role in immune recognition, particularly in presenting viral or tumor antigens to cytotoxic CD8+ T cells, thereby initiating an immune response against infected or malignant cells. It represents a central node in anti-tumor immunity where pathogen-derived epitopes intersect with highly polymorphic human MHC molecules, making it crucial both biologically and clinically for vaccine design and adoptive cellular therapies.
- Other names
- HLA-A*02:01-HPV16 E7 complexHPV16 E7/HLA-A*0201MHC-I/HPV16 E7
02
Mechanism of action
Enhancing CD8+ T cell recognition and killing of HPV16 E7-expressing cells
03
Biological functions
Antigen presentationT cell activationImmune response
04
Disease associations
CancerInfectionHPV-associated cancers
05
Safety considerations
Off-target T cell activationAutoimmune reactionsCytokine release syndrome
06
Biomarkers
HLA-A*02:01 presenceHPV16 E7 expressionCD8+ T cell response
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