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Target intelligence / Profile preview
Human Leukocyte Antigen C*07:02 (HLA-C*07:02)
- Target
- HLA-C*07:02
- Molecular classification
- Class I MHC molecule
01
Overview
HLA-C*07:02 is a specific allele of the HLA-C gene, encoding a class I MHC protein involved in immune recognition. It presents peptides to CD8+ T cells and interacts with NK cell receptors. It is particularly important in controlling CMV infection by presenting immunodominant epitopes. Individuals carrying HLA-C*07:02 have increased susceptibility to drug toxicity when treated with sulfamethoxazole/trimethoprim combination therapy. It can be used for research regarding T-cell responses or developing diagnostic reagents.
02
Mechanism of action
Not applicable
03
Biological functions
Antigen presentationImmune responseNK cell modulation
04
Disease associations
InfectionDrug toxicity
05
Safety considerations
Increased susceptibility to drug toxicity with sulfamethoxazole/trimethoprim
06
Interacting drugs
Sulfamethoxazole/trimethoprim
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