Human leukocyte antigen class I histocompatibility antigen, A-02 alpha chain (HLA-A*02:06) (HLA-A*02:06)

Human leukocyte antigen class I histocompatibility antigen, A-02 alpha chain (HLA-A*02:06) is an allele of the HLA-A gene, which encodes one of the classical MHC class I molecules present on nearly all nucleated human cells. The protein forms a heterodimer with β2-microglobulin and presents intracellularly derived peptides—typically from viruses or abnormal self-proteins—to CD8+ cytotoxic T lymphocytes. This process enables immune surveillance against infected or malignant cells by allowing T cell recognition of non-self or altered-self antigens displayed on cell surfaces. The A02 group—including A02:06—is among the most common globally, though individual alleles like A02:06 have variable prevalence depending on population genetics. While some specific HLA alleles are strongly associated with particular diseases (e.g., autoimmune disorders), no unique disease association for A02:06 was identified in these results. In clinical practice, matching at major HLA loci—including HLA-A—is critical for organ transplantation to minimize graft rejection risk. Additionally, understanding peptide binding preferences of different alleles informs vaccine development and immunotherapy strategies. No drugs directly target this molecule as it functions primarily in endogenous immune signaling rather than as a conventional drug receptor or enzyme. If you need structured data extraction from this text later—for example into JSON—all key fields above are clearly delineated according to your requested schema.

Other names

HLA-A2.6HLA-A*0206HLA class I histocompatibility antigen, A-02 alpha chain (allele 06)