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Target intelligence / Profile preview
Human Papillomavirus Type 18 E7 Antigen Peptide Presented by HLA-DRB1*09:01 (HPV18 E7/HLA-DRB1*09:01)
- Target
- HPV18 E7/HLA-DRB1*09:01
- Molecular classification
- Peptide-MHC Complex, Antigen
01
Overview
This complex consists of a peptide derived from the E7 oncoprotein of Human Papillomavirus type 18 (HPV18), presented by the HLA-DRB1*09:01 molecule. It is a target for CD4+ T cell recognition and is relevant in cancer immunotherapy, particularly for cervical cancer. The E7 protein's role in driving cell cycle progression and inhibiting immune responses makes it a key target. The well-characterized peptide epitope aa84-98 is a frequent target in these complexes.
- Other names
- HPV18 E7 peptide/HLA-DRB1*09:01 complexHPV18 E784-98/HLA-DRB1*09:01
02
Mechanism of action
T cell receptor (TCR) binding and T cell activation leading to cell-mediated cytotoxicity.
03
Biological functions
Antigen presentationT cell activationImmune responseCell cycle regulation (indirectly, via E7)
04
Disease associations
Cervical cancerHPV infection
05
Safety considerations
Off-target T cell activationCytokine release syndromeTumor lysis syndrome
06
Biomarkers
HPV18 E7 expressionHLA-DRB1*09:01 presenceT cell response to HPV18 E7
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