Hyaluronidase 6 (pseudogene) (HYAL6 (occasionally HYAL6P or HYALP1))

Hyaluronidase 6, often referred to as HYAL6 or HYALP1, is a pseudogene within the human hyaluronidase gene family[1][3][4][5]. While the gene is transcribed, a segmental exon deletion prevents translation of a full-length, functional enzyme, leading to premature termination of the peptide[1]. As a result, HYAL6 does not produce a protein product and has no defined physiological, pathophysiological, or therapeutic relevance. The human genome contains five functional hyaluronidase genes (HYAL1–HYAL4, PH-20/SPAM1) and one pseudogene (HYAL6), all clustered on chromosomes 3 and 7[3][4][5]. HYAL6 (pseudogene) is primarily listed in genomic studies for evolutionary context and does not play a direct role in cellular processes, disease, or drug response.

Other names

HYAL6HYAL6PHYALP1