Hydroxyacyl-CoA dehydrogenase trifunctional effector complex subunit beta mRNA 3'-untranslated region (HADHB mRNA 3'-UTR)

The HADHB mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the messenger RNA encoding the beta subunit of the mitochondrial trifunctional protein (MTP) (Source: MedlinePlus, NIH). This region contains specific sequences and structural motifs that serve as binding sites for microRNAs, such as miR-212 and miR-543, and various RNA-binding proteins that collectively govern the stability and translation efficiency of the HADHB transcript (Source: PubMed). By controlling the abundance of the HADHB protein—an enzyme essential for the final step of long-chain fatty acid beta-oxidation—the 3'-UTR plays a pivotal role in cellular energy metabolism and lipid homeostasis (Source: Wikipedia). Dysregulation of this regulatory axis is implicated in metabolic disorders like mitochondrial trifunctional protein deficiency (MTPD) and has been observed in several cancers where metabolic reprogramming supports tumor growth and survival (Source: NIH, PubMed). Therapeutically, the HADHB mRNA 3'-UTR is an emerging target for RNA-based interventions, such as antisense oligonucleotides (ASOs) or microRNA mimics, aimed at restoring enzyme levels in genetic deficiencies or modulating metabolism in oncological contexts (Source: PubMed). While the HADHB protein itself can be inhibited by drugs like trimetazidine, there are currently no FDA-approved therapies that specifically target the mRNA 3'-UTR (Source: DrugBank).

Other names

HADHB 3'-UTR3'-untranslated region of HADHBTrifunctional enzyme subunit beta mRNA 3'-UTRTP-beta mRNA 3'-UTRECHB mRNA 3'-UTR

Modulation of mRNA stability and translation through steric hindrance of microRNA binding or recruitment of RNA-regulatory complexes.