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Hydroxypropyl Guar (HP-guar) (HP-guar)
- Target
- HP-guar
- Molecular classification
- Polysaccharide, Polymer, Gelling agent, Demulcent
01
Overview
Hydroxypropyl guar (HP-guar) is a modified natural polysaccharide used in artificial tear formulations to stabilize the tear film in patients with dry eye disease. It forms a gel matrix on the ocular surface upon contact with tear components, improving lubrication, prolonging retention time, and reducing evaporation.
- Other names
- HP-GuarHydroxypropylguarIn situ gelling agent (ophthalmic)Systane Complete
02
Mechanism of action
In situ gel formation triggered by borate ions and divalent cations present in tears, resulting in a cross-linked matrix that adheres to the ocular surface, prolonging retention time of lubricants and demulcents.
03
Biological functions
Tear film stabilizationLubricationBioadhesionWater retentionOcular surface protection
04
Disease associations
Dry eye disease
05
Safety considerations
Potential for allergic reactions or hypersensitivityPossible blurring of vision immediately after applicationRare instances of ocular irritation or discomfort
06
Interacting drugs
Artificial tears
1 more in the full profile.
07
Biomarkers
Tear break-up time (TBUT/NITBUT)Lipid layer thickness (LLT)Tear meniscus height (TMH)
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