Ileal bile acid-binding protein (FABP6) (FABP6)

Ileal bile acid-binding protein (FABP6), also known as gastrotropin, is a member of the intracellular lipid-binding protein (iLBP) family specifically expressed in the villi of the distal ileum (UniProt P51161). Its primary biological role is the high-affinity binding and intracellular transport of bile acids, facilitating their movement from the apical sodium-dependent bile acid transporter (ASBT) to the basolateral membrane for secretion into the portal circulation (PubMed: 25533013). FABP6 is a key component of the enterohepatic circulation and acts as a metabolic sensor by delivering bile acids to the farnesoid X receptor (FXR), which regulates bile acid synthesis and glucose homeostasis (PubMed: 12663518). In clinical contexts, FABP6 is frequently overexpressed in colorectal adenomas and carcinomas, suggesting a role in promoting cell proliferation and survival in response to high bile acid levels (PubMed: 16331255). Consequently, it is investigated as both a biomarker for early-stage colorectal cancer and a therapeutic target for metabolic syndromes and cholestatic liver diseases. Research into FABP6 inhibitors aims to disrupt the reabsorption of bile acids to lower systemic levels and modulate metabolic pathways. The protein's unique expression pattern and specific ligand binding make it an attractive site for tissue-specific pharmacological intervention.

Other names

GastrotropinFatty acid-binding protein 6I-BABPILBPI-BALPIleal lipid-binding protein

Inhibition of intracellular bile acid transport and modulation of FXR-mediated gene expression (PubMed: 25533013, 12663518).